ABSTRACT
Xiebaisan, which is one of the famous classical formulas in the Catalogue of Ancient Famous Classical Formulas (The First Batch) published by the National Administration of Traditional Chinese Medicine (TCM) in 2018, is derived from the Xiao' er Yaozheng Zhijue with definite clinical effect. By means of bibliometrics, 118 relevant ancient book data were collected, including 75 ancient books of TCM. It was found that the main symptoms of Xiebaisan had been expanded in the past dynasties. For example, the adaptive population of Xiebaisan had been extended from children to women and adults, and the scope of symptoms and signs had also been extended from pediatrics to internal medicine and gynecology. Meanwhile, the names, pathogenesis and syndromes of diseases are also described extensively, although the dosage ratio is different, the compatibility ratio of Mori Cortex, Lycii Cortex and Glycyrrhizae Radix et Rhizoma is relatively constant, and the decoction method is mostly followed by decocted power. At the same time, doctors in Ming and Qing dynasties have made a lot of general comments on explanation of this formula, but there is little controversy.
ABSTRACT
The research and development of classical famous prescriptions is an important way to actively promote the development of traditional Chinese medicine.It is particularly important to sort out the historical evolution of the composition of traditional famous prescriptions to make clear the origin，producing areas and concocting methods of traditional Chinese medicine，which is the source of ensuring the safety and efficacy.Through literature review，it is found that at present，the research of mulberry white skin focuses on chemical composition，pharmacological mechanism and modern clinical research，and there are few ancient literature studies.Therefore，based on the ancient literature，the author conducts a comprehensive textual research on mulberry bark from its name，origin，producing areas and concocting methods and other aspects，in order to provide literature reference for the research and development of the prescription involving mulberry bark in the classic prescription.Through research，we can know that there are more than 20 aliases of mulberry bark，and the most commonly used names in modern times are "sangbaipi""sanggenbaipi""sangpi"，etc.In Tang and Song dynasties and before，mulberry bark was mainly composed of Morus alba var. alba and jisang，after Tang and Song dynasties，mulberry bark plant sources showed diversity，in modern times，Morus alba var. alba was gradually identified as the main medicinal species of mulberry bark.Therefore，it is suggested that Morus alba var. alba be selected as the plant source of mulberry bark.According to ancient books，mulberry trees are cultivated everywhere，with Jiangsu，Zhejiang and Sichuan as the best areas，and Henan and Anhui as the most popular areas in modern times.The conclusion of ancient and modern quality of mulberry bark is basically the same，the root skin is white，thick and sweet.The morden concocting methods of mulberry bark mainly include raw mulberry bark，honey mulberry bark and fried mulberry bark.According to the textual research of ancient literature，in addition to the above three kinds of medical specifications，there have been concocting methods without auxiliary materials，such as burning，baking and roasting，as well as concocting methods with auxiliary materials，such as bran roasting，rice swill soaking，honey wine roasting，etc.The concocting methods of mulberry bark used by the classical famous recipe should be selected in combination with specific drug provisions.